Blackstaff ward sits in the southwest of the city centre, bordering the River Lagan. The area is primarily defined by industrial and commercial infrastructure, including significant warehousing and transport links. The George Best Belfast City Airport is located within its boundaries, contributing to a landscape of light industry and logistics operations. This functional character shapes much of the ward's environment and daily activity.
The residential population is concentrated in the Donegall Road and Village areas, which contain terraced housing. The National Football Stadium at Windsor Park is a central landmark here, hosting major sporting events. The ward also contains sections of the Boucher Road, known for its retail parks and playing fields. Urban green spaces are provided by Ormeau Park, which stretches along the riverbank on its eastern edge.