Lissan ward sits in the southwest of Mid Ulster, bordering County Londonderry. The landscape is predominantly rural, characterised by rolling drumlins and agricultural land. The area is centred around the village of Lissan itself, with smaller settlements like Straw and Ballynagarrick dispersed throughout. The main transport artery is the A29 road, which runs north-south connecting to Cookstown.
The ward's history is deeply connected to the Lissan Estate, a large demesne with a historic house that was home to the Staples family for centuries. The estate's grounds and woodlands shape the local environment. The area includes part of Lough Fea, a reservoir offering walking paths and fishing, which serves as a recreational focus for the community.